otezla in mexico

Remember that stress is the biggest factor in aggravating psoriasis and moving so often is stressful. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF- or the inhibition of PDE4. In Mexico, I could simply go to a pharmacy and ask for the box of Methotrexate, no questions asked. Se observaron tasas de respuesta similares en todos los intervalos de peso. Recent Otezla Growth: A Result of the Amgen Acquisition or Benefiting While we paid a significant amount of money for US health insurance as self-employed, my insurance had no issues with anything and I was happy. A drug company seeking approval to market a generic equivalent must refer to the Reference Listed Drug in its Abbreviated New Drug Application (ANDA). Amgen Inc. does not control or endorse this third-party website. P.S. Im not surprised that Utah insurance companies prefer to send people to Mexico to get their drugs and come back. Estas mejoras se mantenan en la semana 24. At 20, I embarked on a mission to see the world while building my career through studying and working abroad. 5. Otezla (apremilast) is a brand-name prescription drug that's used to treat certain autoimmune conditions. La mejora en las puntuaciones en HAQ-DI se mantuvo en la semana 24. Farmacia Especializada sells a lot of expensive medicine, but its still a Mexican-style pharmacy which means its a pretty open-air type of shop with counters almost on the street. Oral ulcers associated with Behets Disease. Answered in 1 hour by: 3/16/2017. Otezla is a brand name of apremilast, approved by the FDA in the following formulation (s): OTEZLA (apremilast - tablet;oral) Manufacturer: AMGEN INC Approval date: March 21, 2014 Strength (s): 10MG [ RLD] [ AB], 20MG [ RLD] [ AB], 30MG [ RLD] [ AB] Has a generic version of Otezla been approved? No se observaron dichos efectos cuando la exposicin en los animales fue a dosis 1,3 veces la exposicin clnica. Im sorry to disappoint, but psoriasis isnt something that can be cured forever as theres no forever fix to an overactive immune system. Growing up I did that a military dependent but as an adult I have moved sharply less often being in my 2nd home in 44 years of marriage. The problem is that biological immunosuppressant drugs are insanely expensive due to patent issues, hence why affordable alternatives cannot enter the market until 2022. If youve been dealing with psoriasis for some years now you might know exactly what Im talking about. One doctor said the only way I could get it would be to go through the entire therapy with topical creams, UV lights, and Methotrexate, confirm its failure again, then check myself to a hospital and maybe Id be able to receive it there. When youre working remotely while traveling, this can sometimes lead to an unhealthy lifestyle. Ask your doctor about other potential side effects. I require 90mg / 4 weeks, but get it every 8 weeks instead. Exclusivity is the sole marketing rights granted by the FDA to a manufacturer upon the approval of a drug and may run simultaneously with a patent. No hubo interacciones medicamentosas farmacocinticas entre apremilast y los anticonceptivos orales que contienen etinilestradiol y norgestimato. PRECAUCIONES GENERALES: Los pacientes con intolerancia hereditaria a galactosa, de insuficiencia de lactasa de Lapp o problemas de absorcin de glucosa o galactosa no deben tomar este medicamento. Artritis Psorisica: Est indicado para el tratamiento de artritis psorisica activa (PsA) en pacientes adultos. By saying that I knew what to expect I knew that Id feel bad after it, as its a strong dangerous drug and its often used to treat cancer, in bigger doses naturally. Would you mind sharing how/where you finally managed to get your prescription for Stelara? La administracin concomitante de apremilast con dosis mltiples de rifampicina produjo una disminucin en el rea bajo la curva de concentracin plasmtica (AUC) de apremilast y de la concentracin srica mxima (Cmx) aproximadamente del 72% y del 43%, respectivamente. Although there is an approved generic version of Otezla, it is not currently available on the market. Un total del 18% de los pacientes tena historia de artritis psorisica. I found mine made errors and this may be common. Prdida de peso: El peso de los pacientes se determin de forma rutinaria en los estudios clnicos. Distribucin: La unin de apremilast a las protenas plasmticas humanas es aproximadamente del 68%. Its my mission to teach YOU how can you turn YOUR dreams of travel and career, into reality. El criterio principal de valoracin fue el porcentaje de pacientes que obtuvieron una respuesta ACR20 en la semana 16 conforme a los criterios del Colegio Americano de Reumatologa (ACR por sus siglas en ingls, American College of Rheumatology). Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed. Adems, se demostr el beneficio del tratamiento con apremilast en mltiples manifestaciones de la psoriasis, incluyendo prurito, enfermedad ungueal, afectacin de piel cabelluda medidas de calidad de vida. Debido a que apremilast es un sustrato de CYP3A4, la exposicin de apremilast disminuye cuando se administra concomitantemente con rifampicina, un inductor potente de CYP3A4. Official answer. This form does not ask what your net worth is. I noticed you got the prescription at the pharmacy. En el estudio ESTEEM 1, aproximadamente el 61% de los pacientes reasignados aleatoriamente a apremilast en la semana 32 tenan una respuesta PASI-75 en la semana 52. En caso de sobredosis, se recomienda monitorizar al paciente para detectar cualquier signo o sntoma de efectos adversos e instaurar el tratamiento sintomtico adecuado. And more importantly, it costs only 68,500 MXN (approx. Amgen Announces Positive New Data at Eadv 2022 for Otezla (Apremilast) En los estudios ESTEEM 1 y ESTEEM 2 se demostraron mejoras significativas en la calidad de vida, como determinaron el ndice de calidad de vida en dermatologa (DLQI) y el SF-36v2MCS, en los pacientes tratados con apremilast en comparacin con los tratados con placebo (Tabla 2). Tell your Fertilidad: No hay datos de fertilidad disponibles en seres humanos. Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its () isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. But, it turned out to be easier than ever, but frankly, if I didnt speak fluent Spanish I would have had to ask someone to do it for me. Sarah's plaque psoriasis made her want to hide her skin. Se han observado casos de ideacin y comportamiento suicida, incluido el suicidio, en pacientes con y sin antecedentes de depresin. c PASI = ndice de gravedad y rea de la psoriasis. Upon my arrival in Mexico City I checked the pharmacy website in the morning to see if Stelara is available It was. Proporcin de pacientes con respuestas ACR en los estudios PALACE 1, PALACE 2 y PALACE 3 y en los estudios agrupados en la semana 16. Otezla (apremilast) is indicated for the treatment of adult patients with plaque psoriasis who are candidates for phototherapy or systemic therapy. When I finally give up on signing up for national health insurance in Italy and Poland, as we werent able to do either, I thought Id just use my savings and pay for my medicine out of pocket until were able to get on the US health insurance again. Knowing what I know about my illness and by researching a lot I decided to treat myself. Se observ una reduccin de los pesos fetales y una osificacin retardada del hueso supraoccipital del crneo con las dosis de 40 y 80 mg/kg/da. In vitro, apremilast tiene escaso o ningn efecto inhibidor (CI50 > 10 M) en el transportador de aniones orgnicos (OAT por sus siglas en ingls, Organic Anion Transporter) 1 y OAT3, el transportador de cationes orgnicos (OCT por sus siglas en ingls, Organic Cation Transporter) 2, el polipptido transportador de aniones orgnicos (OATP) 1B1 y OATP1B3, o en la protena resistente al cncer de mama (BCRP por sus siglas en ingls, Breast Cancer Resistance Protein), y no es un sustrato de estos transportadores. El beneficio clnico de apremilast se demostr en mltiples subgrupos definidos por las caractersticas demogrficas basales y las caractersticas clnicas basales de la enfermedad (incluidos la duracin de la enfermedad psorisica y los pacientes con historia de artritis psorisica). En los ensayos clnicos en pacientes con psoriasis, apremilast disminuy el grosor epidrmico de la piel lesionada, la infiltracin celular inflamatoria y la expresin de los genes proinflamatorios, incluidos aquellos que codifican para el xido ntrico sintasa inducible (iNOS), IL-12/IL-23p40, IL-17A, IL-22 e IL-8. In certain instances, a number is added to the end of the AB code to make a three character code (e.g. your weight regularly. As a digital nomad with no health insurance (no travel insurance covers chronic conditions) my options were limited to self-funded drugs. Im not talking about not covering my biological drugs but rejecting me from the insurance. a FAS (Full Analysis Set) = Conjunto de anlisis completo. En general, se alcanzaron las respuestas en el PASI en la semana 16 y se mantuvieron hasta la semana 32. Ive been wanting to quit Methotrexate, as you cannot take it for 6 months before even thinking of getting pregnant. Talk to one of the physician's assistants before your first meeting if you can. No es necesario un ajuste de la dosis en pacientes con insuficiencia heptica. Im approximately 2 hours from the Juarez, MX border Also curious if you have to see a dermatologist in Mexico for a scrip before purchasing the biological from a pharmacy and how Id go about finding a dermatologist that could write a script for it. Los sujetos sin datos contaron como no respondedores. Everyones impression was that once you actually have the insane amount of money to pay for a medicine you need, youll be able to get it. Las respuestas observadas en el grupo tratado con apremilast fueron similares entre los pacientes que recibieron y los que no recibieron FAMEs de forma concomitante, incluido MTX. Not for Stelara I'm afraid. Aceptar. To pay less for Otezla, you can participate in a manufacturer savings program or a patient assistance program. OTEZLA (apremilast) is an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4) specific for cyclic adenosine monophosphate (cAMP). Eliminacin: El aclaramiento plasmtico medio de apremilast es de unos 10 l/h en sujetos sanos, con una semivida de eliminacin terminal de 9 horas aproximadamente. Se puede administrar apremilast de forma concomitante con anticonceptivos orales. En el estudio ESTEEM 2, aproximadamente el 80,3% de los pacientes reasignados aleatoriamente a apremilast en la semana 32 tenan una respuesta PASI-50 en la semana 52. Lactancia: Se ha detectado apremilast en la leche de ratones hembra en periodo de lactancia. If unexplained or significant weight loss occurs, your doctor will decide if you should As Ive had experience with this drug before I knew what to expect, double-checked the right dosage and controlled my blood tests, which can also be cheaply done in Mexico. The most common side effects of Otezla include diarrhea, nausea, upper respiratory tract infection, tension headache, and headache. En general, la mayora de las reacciones adversas se consideraron de intensidad leve o moderada. Las mejoras, en general, se mantuvieron en los sujetos que fueron reasignados aleatoriamente a OTEZLA en la semana 32 hasta la semana 52 (Tabla 3). Click "OK" to proceed or "CANCEL" to return to otezla.com. Have you or anyone else ever tried to get that reimbursement for purchases made in Mexico? Se observaron un aumento del nmero de resorciones tempranas y una disminucin del nmero de tarsos osificados con las dosis de 20, 40 y 80 mg/kg/da. These medications may be counterfeit and potentially unsafe. Hence why no insurance company wants to pay for them. This is when I turned to my good old Mexico for help again. Just yourself, nothing ;-) Posologa: La dosis recomendada de apremilast es de 30 mg dos veces al da por va oral, por la maana y por la noche, cada 12 horas aproximadamente, sin restricciones de alimentos. Find one who has been doing this for a number of years if you can. Otezla | European Medicines Agency Traveling Alone with a Baby: It Can Be Done (& Fun)! I have that card now, and unfortunately no - that won't work, because you cannot use this card to pay for the medicine abroad. Reporte las sospechas adversas a los correos: farmacovigilancia@cofepris.gob.mx y a smexico@celgene.com. The whole process took about 10 minutes, no questions asked. The system isnt ideal, leaving many without health coverage due to high insurance prices, but as pharma companies keep increasing prices of drugs out of green, the insurance gets more expensive. ej., nmero de articulaciones inflamadas, nmero de articulaciones dolorosas/doloridas, dactilitis y enteritis) y en las manifestaciones cutneas de psoriasis en los pacientes tratados con apremilast. The U.S. government estimates that close to 1 million people in California alone cross to Mexico annually for health care, including to buy . Otezla was first approved for the treatment of psoriatic arthritis on March 21st, 2014 by the FDA and was on the market soon after (by the end of March 2014). By the time I moved to Playa del Carmen in Mexico my psoriasis was a complete mess, as you could see in some of my photos. ej., rifampicina) y puede dar lugar a una respuesta clnica reducida. Biotransformacin: Apremilast se metaboliza extensamente por las vas mediadas por CYP y no mediadas por CYP, incluidas las vas de oxidacin, hidrlisis y conjugacin, lo que sugiere que no es probable que la inhibicin de una nica va de aclaramiento cause una interaccin medicamentosa destacable. (Because home values have been increasing here in the states, this and a small nest egg would disqualify many applicants from this program in years past.) Methods of treating, managing or preventing psoriatic arthritis are disclosed. Stop using Otezla and call your healthcare provider or seek emergency help right away if you develop any of the following symptoms of a serious allergic reaction: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms. Netherlands wont send your medical history, Italian hospital decided not to accept me, pharmaceutical companies increased prices, 20 Best Traditional Polish Foods You'll Love, Best Travel Strollers: Honest & Updated Reviews, Best Ride On Suitcases for Toddlers (Kids Luggage for Travel), Things to Know Before Renting a Car in Italy, 25 Interesting Facts About Mexico You Probably Don't Know, Marrakech Travel Tips: What to Know Not to Get Disappointed. Entre los pacientes que fueron inicialmente aleatorizados al tratamiento con 30 mg de apremilast dos veces al da, el cambio con respecto a la situacin basal en la puntuacin en HAQ-DI en la semana 52 fue de 0,333 en el grupo de 30 mg de apremilast dos veces al da en un anlisis agrupado de la fase abierta de los estudios PALACE 1, PALACE 2 y PALACE 3. In Mexico, most drugs are available over the counter. When we moved to the US and set up health insurance, I was able to see the dermatologist and after explaining what Ive been taking, showing photos and the stages of my skin, I was able to receive the correct biological drugs without any issues. identical active ingredients, dosage form, and routes of administration) and having the same strength (see Therapeutic Equivalence-Related Terms, Pharmaceutical Equivalents) generally will be coded AB if a study is submitted demonstrating bioequivalence. Otezla can cause allergic reactions, sometimes severe. I've got an autoimmune disease that's so rare there aren't many treatments indicated for it yet aside from Prednisone. 3. As you can see medical tourism in Mexico has saved me twice. Thank you! Quite often tourists and locals go to Mexico just to buy medicines, as theyre available over the country and are much cheaper. Second: AbbieVie did offer the program in the past but this year they eliminated the need to report your 'net worth.' La farmacocintica de apremilast es lineal, con un aumento proporciona la dosis en la exposicin sistmica en el intervalo de dosis de 10 a 100 mg al da. La inhibicin de PDE4 eleva los niveles intracelulares de AMPc, que a su vez regula disminuyendo la respuesta inflamatoria mediante modulacin de la expresin de TNF-, IL-23, IL-17 y otras citocinas inflamatorias. Even though Ive lived in Mexico City before and wandered around Zocalo (historic center) a bunch of times, I never noticed a whole street filled mostly with pharmacies. Pacientes de edad avanzada: No se requiere un ajuste de la dosis en esta poblacin de pacientes. Patents are granted by the U.S. Patent and Trademark Office at any time during a drug's development and may include a wide range of claims. Estudios de genotoxicidad: Apremilast no es genotxico. Terms, conditions, and program maximums apply. Los pacientes de estos estudios tenan un diagnstico de artritis psorisica desde al menos 6 meses. Want to share your story or concern? Otezla is the only pill approved to treat mild, moderate, and severe plaque psoriasis. En un estudio combinado de toxicidad en el desarrollo embriofetal y de fertilidad en ratones hembra con dosis orales de 10, 20, 40 y 80 mg/kg/da se observaron una prolongacin de los ciclos estrales y un mayor tiempo hasta el apareamiento con las dosis de 20 mg/kg/da y superiores. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. In my case, Ive left myskin without any treatmentor care, and as a result, I was almost completely covered in psoriasis spots. Entre los 497 pacientes inicialmente aleatorizados a 30 mg de apremilast dos veces al da, 375 (75%) pacientes seguan con este tratamiento en la semana 52. En los ratones, el NOEL en el desarrollo y en la madre fue de 10 mg/kg/da (1,3 veces la exposicin clnica). La acumulacin es mnima cuando apremilast se administra una vez al da y aproximadamente del 53% en sujetos sanos y del 68% en pacientes con psoriasis cuando se administra dos veces al da. Generic Otezla Prices (Apremilast) - U.S. & International Tell your doctor about any side effect that bothers you or does not go away. El tratamiento con apremilast produjo una mejora significativa de la psoriasis en placas de moderada a grave, como demostr la proporcin de pacientes con respuesta PASI-75 en la semana 16, en comparacin con placebo. # Al menos una de estas reacciones adversas fue notificada como grave. If you started following me, my Instagram and my blog recently you probably thought that Im just like any other woman, carefreely traveling the world in pretty outfits. Se observaron respuestas ACR similares en los pacientes con diferentes subtipos de artritis psorisica, incluida la artritis en las articulaciones IFD. Note One: Use the AbbieVie website for the most current form YOU will need to file. How long has Otezla been on the market? - Drugs.com Im retired and on Medicare and have just been prescribed this for my psoriasis. En un estudio de toxicidad en el desarrollo embriofetal en monos, dosis orales de 20, 50, 200 y 1000 mg/kg/da dieron lugar a un aumento, relacionado con la dosis, de prdidas prenatales (abortos) con las dosis de 50 mg/kg/da y superiores; no se observ ningn efecto relacionado con el medicamento del ensayo en las prdidas prenatales a la dosis de 20 mg/kg/da (1,4 veces la exposicin clnica). Estas reacciones adversas ocurrieron por lo general en las 2 primeras semanas de tratamiento y normalmente remitieron en 4 semanas. Resumen del perfil de seguridad: Las reacciones adversas notificadas con mayor frecuencia en los estudios clnicos de fase III fueron trastornos gastrointestinales (GI) que incluyen diarrea (15,7%) y nusea (13,9%). Se debe reducir la dosis de apremilast a 30 mg una vez al da en pacientes con insuficiencia renal grave (Filtracin Glomerular estimada [FGe] menor de 30 ml/min/1,73 m2 o CLcr < 30 ml/min). Working long hours or during awkward times without a routine or schedule can make one stressed or tired, especially if you have clients in different time zones. Por lo tanto, es poco probable que ocurran interacciones medicamentosas clnicamente relevantes cuando apremilast se administre concomitantemente con medicamentos que son sustratos o inhibidores de estos transportadores. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of complications from having severe diarrhea, nausea, or vomiting. Hence why it was surrounded by a few security guards. Apremilast se somete a un metabolismo extenso y slo el 3% y el 7% del compuesto original administrado se recuperan en orina y en heces, respectivamente. CONTRAINDICACIONES: Hipersensibilidad al principio activo o a alguno de los excipientes de la frmula. Los pacientes que no alcanzaron la respuesta designada en el PASI en la semana 32, o que fueron inicialmente aleatorizados a placebo, siguieron con apremilast hasta la semana 52. In the Netherlands, despite my health insurance and prescription I had to pay 55 Euros a month for these pills and required weekly visits at the hospital for a check-up. Insanely expensive even with my Medicare and secondary insurance coverage really cost prohibitive! By visiting different doctors in public and private sectors in Poland, United Kingdom, United States, Netherlands or Mexico I saw that dermatologists simply arent always able to follow up with every single new drug for psoriasis that comes out. Don't do this. The cost for Otezla oral tablet (10 mg-20 mg-30 mg) is around $4,854 for a supply of 55 tablets, depending on the pharmacy you visit. Es necesario un programa inicial de titulacin de dosis como se muestra en la Tabla 5. You are encouraged to report negative side effects of prescription drugs to the FDA. Se observ un aumento del nmero de muertes perinatales y posnatales de las cras y una reduccin en la ganancia de peso de las cras durante la primera semana de lactancia con dosis 80 mg/kg/da ( 4,0 veces la exposicin clnica). PDE4 inhibition results in increased intracellular cAMP. No one has asked me to show proof of previous medical history (which would be difficult, as the Netherlands wont send your medical history to the US for instance), told to try stupid not working topical treatments all over again. One might say that we need doctors to tell us what to do and what medicines to take, and while its true you also know your body best. I have a couple questions : 1. receiving Otezla continued on the assigned therapy for an additional year). Fenner is not the only one thinking like this. La respuesta a apremilast fue rpida, con mejoras significativamente mayores en los signos y sntomas de la psoriasis, incluido el PASI, malestar/dolor en la piel y prurito, en comparacin con placebo en la semana 2. En los estudios ESTEEM 1 y ESTEEM 2, se observaron mejoras significativas (reducciones) en la psoriasis ungueal, como determin el cambio porcentual medio en el ndice de gravedad de la psoriasis ungueal (NAPSI por sus siglas en ingls, Nail Psoriasis Severity Index) con respecto al basal en los pacientes tratados con apremilast, en comparacin con los tratados con placebo en la semana 16 (p < 0,0001 y p = 0,0052, respectivamente). A drug patent is assigned by the U.S. Patent and Trademark Office and assigns exclusive legal right to the patent holder to protect the proprietary chemical formulation. Se puede administrar apremilast de forma concomitante con un inhibidor potente de CYP3A4 como ketoconazol. Speaking Spanish, traveling, and paying for the drug are no problem if I can find a way to get a prescription. Otezla is a brand name of apremilast, approved by the FDA in the following formulation(s): A generic version of Otezla has been approved by the FDA. Pacientes con peso ms bajo del normal: Se debe monitorizar peridicamente el peso de los pacientes que, al comienzo del tratamiento, tengan un peso inferior al normal. Since I left the Netherlands back in 2014 Ive been bouncing between the US and London for a while, but without a proper base. Otezla. Los pacientes que fueron reasignados a placebo y que perdieron la respuesta PASI-75 (ESTEEM 1) o que perdieron el 50% de la mejora en el PASI en la semana 32 en comparacin con la situacin basal (ESTEEM 2) volvieron a recibir tratamiento con 30 mg de apremilast dos veces al da. Si los pacientes presentan sntomas psiquitricos nuevos o los que ya presentaban se agravan, o si se identifica un episodio de ideacin suicida o intento de suicidio, se recomienda interrumpir el tratamiento con apremilast. La incidencia global de reacciones adversas graves fue baja y no indic afectacin de ningn rgano ni sistema especfico. Exclusivity is a statutory provision and is granted to an NDA applicant if statutory requirements are met. Resumen de las reacciones adversas en artritis psorisica (APs) y/o psoriasis (PSOR), Infeccin del tracto respiratorio superior, Trastornos del metabolismo y de la nutricin, Trastornos respiratorios, torcicos y mediastnicos, Trastornos de la piel y del tejido subcutneo, Trastornos musculoesquelticos y del tejido conjuntivo, Trastornos generales y alteraciones en el lugar de administracin. PDE4 inhibition results in . Su venta requiere receta mdica. Absorcin: Apremilast se absorbe bien, con una biodisponibilidad oral absoluta del 73% aproximadamente y concentraciones plasmticas mximas (Cmx) que se alcanzan en una mediana de tiempo (tmx) de 2,5 horas aproximadamente. About Otezla (apremilast) OTEZLA (apremilast) is an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4) specific for cyclic adenosine monophosphate (cAMP). Specific methods encompass the administration of apremilast in specific dosage titration schedule, alone or in combination with a second active agent. Otezla (apremilast) is a prescription medicine used to treat adult patients with: Plaque psoriasis for whom phototherapy or systemic therapy is appropriate. Exclusivity periods can run from 180 days to seven years depending upon the circumstance of the exclusivity grant. My doctor and I decided to try Stelara, one dose every three months that I had to inject myself with. Thank you for all you knowledge about the prescription woes! doctor about all the medicines you take, including prescription and nonprescription medicines. *The Otezla Co-Pay Card is for eligible commercially insured patients. Not everyone responds to Otezla, and those who do respond may respond differently. Otezla for psoriasis, I took in the past and had no issues - JustAnswer If you have certain medical conditions, your doctor may recommend that you use Otezla. Las otras reacciones adversas notificadas con mayor frecuencia incluyeron infecciones del tracto respiratorio superior (8,4%), cefalea (7,9%) y cefalea tensional (7,2%). Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed.

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